Weight loss medications like Mounjaro have helped countless people achieve their weight loss goals, improve their health and find new confidence. Here, our experts unpack how Mounjaro works, what to expect on your journey as well as real patient transformations to help you figure out if weight loss medication is right for you.
Mounjaro is an FDA-approved medication for the treatment of type 2 diabetes. While it is currently under review for the treatment of obesity, some healthcare providers may prescribe it off-label for this use. [1]
Mounjaro is administered as a once-weekly subcutaneous injection (into the fatty tissue just under the skin) and should be used alongside a reduced calorie diet and increased physical activity.
It contains the active ingredient tirzepatide, which mimics the effects of two naturally occurring gut hormones: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). These hormones help regulate blood sugar levels, slow digestion, and promote a feeling of fullness.
Mounjaro helps manage type 2 diabetes through:
Mounjaro helps the body manage blood sugar more effectively by improving the function of insulin-producing cells in the pancreas (called beta cells). It makes these cells work more efficiently, so they release insulin in a more balanced way. Mounjaro also lowers insulin levels when fasting, reduces insulin resistance, and boosts hormones that help the body use insulin better. [3]
Since starting her weight loss journey with Levity, Zion has lost 25 lbs in 6 months using Mounjaro.
For the past seven years Zion has struggled to lose weight, impacting her confidence and her desire to date. However, since starting weight loss medication she has found herself going to more social events which she used to avoid and is more hopeful about dating. “It’s been great for my confidence and even my friends have been noticing that in me as well. So, it's done wonders,” says Zion.
Plus, when it comes to continuing her weight loss journey Zion feels hopeful because she knows she’s only just getting started. “It honestly really has made me feel like I can definitely move goal posts and it makes me feel like I'm definitely going to be able to get to my goal… and I just didn't think that was ever possible before.”
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Clinical trials indicate that Mounjaro may result in greater weight loss compared to Wegovy, with participants losing up to 20.9% of their body weight over 72 weeks on Mounjaro, [4] versus 14.9% over 68 weeks on Wegovy. [5] Both medications can cause side effects such as nausea, vomiting, and gastrointestinal issues. Patients should consult their healthcare provider to determine which medication is best suited for their specific needs.
Mounjaro is highly effective across different populations for weight loss and blood sugar control. In clinical trials, there were no differences observed in the efficacy of Mounjaro in elderly populations.
Although Mounjaro has not been studied in human pregnancy, it shouldn’t be used by pregnant women as it has been shown to cause reproductive toxicity in animal studies. Due to this, Mounjaro should be discontinued at least 2 months before a planned pregnancy.
Mounjaro has been shown to help people lose up to 20.9% of their body weight in 72 weeks. [4]
Based on the above clinical trial, you can expect to lose an average of around 6% of your body weight by your second month of treatment, 9% by your third month and 21% after 16.5 months (72 weeks) of long-term treatment.
As with any medication, individual responses to Mounjaro can vary greatly. Some people may experience rapid weight loss, while others may see slower results. Your starting weight and body composition can impact the rate and extent of weight loss.
Lifestyle factors could influence initial weight loss results. Eating a healthy, calorie-controlled diet is crucial for maximizing weight loss on Mounjaro. Focusing on whole, nutrient-dense foods while avoiding processed foods is so important.
In addition, regular physical activity, including a mix of aerobic exercises and strength training, can enhance weight loss outcomes.
The most common side effects of Mounjaro are gastrointestinal. At the highest dose (15 mg), nausea was reported in 31% of patients, diarrhoea in 23%, vomiting in 12.1%, constipation in 11.7%, and indigestion in 11.3%. [4]
Serious side effects with Mounjaro are rare, but it’s important to be aware of them. Here’s what to look for.
Mounjaro should never be used in people who have a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2). This is due to the potential risk of thyroid cancer associated with Mounjaro. As a result, Mounjaro carries an FDA black-box warning.
Mounjaro is approved for use when used alongside a reduced calorie diet and increased physical activity. Lifestyle changes and habits that can influence your weight loss success include:
Make sure you are eating a balanced diet rich in whole foods like fruits, vegetables, lean proteins, and whole grains. [6] Avoid or limit processed foods, added sugars, and saturated fats. Include high-fibre foods to help keep you full and support digestive health. [7]
Aim for 150 minutes of moderate exercise in a week. This can be broken down into 30-minute sessions over 5 separate days. Include activities like walking, cycling, or swimming to get your heart rate up and burn calories. [8]
Be sure to include some strength training too - muscle training helps maintain muscle mass and metabolism, supporting long-term weight management. [9]
It’s a good idea to try and eat slowly and mindfully. Pay attention to hunger and fullness cues to avoid overeating, and use smaller plates and measure out food portions to ensure you maintain a calorie deficit. [10]
Drinking plenty of water each day helps control hunger and supports metabolism. Current recommendations are that adults consume about 2.7 liters (11.5 cups) of total fluid per day for women and 3.7 liters (15.5 cups) for men. This includes fluids from all sources, including water, other beverages, and food. [11]
By prioritising your sleep and aiming for 7-9 hours per night, your overall health will improve. Evidence also suggests it helps to balance hormones involved in appetite regulation. [12]
Mounjaro is approved for weight loss when combined with a reduced calorie diet and increased physical activity.
To get the best results, focus on eating a healthy, balanced diet with plenty of high-fiber foods, whole grains, and lean proteins. This will help you feel full and ensure you're getting the nutrients your body needs.
Try to get at least 150 minutes of moderate-intensity exercise each week. This could include activities like brisk walking, cycling, or dancing. Adding resistance training to your routine can also help build muscle mass, which boosts metabolism and supports weight management.
Levity can help boost your results alongside a healthy diet and regular exercise. Weight loss injections need to be prescribed by a healthcare professional, who assesses whether these medications are suitable for you. Find out if you’re eligible here.
References
Probiotics play an important role in keeping our guts healthy and supporting digestion. But what exactly are they, and can they help you lose weight? Read on to hear from our Levity experts.
In clinical trials participants lost 7-15% of their body weight after a year with semaglutide, the active ingredient in Ozempic.
How much does Ozempic cost to buy online? You can get the same ingredient as Ozempic and Wegovy for up to 85% less. Here is your guide to buying weight loss treatments.
