Managing Side Effects Of GLP-1 Weight Loss Medication
Starting weight loss medication is an exciting step but like any other medication it's important to understand the potential side effects and how to effectively manage them.
Whether you’ve been taking GLP-1 treatments for a while or you’re just getting started, it’s likely that you’ve heard about the importance of fiber for weight loss. In reality, no amount of fiber can take the place of a healthy diet, regular exercise or weight loss medications like Mounjaro and Wegovy. The good news is that fiber supplements like psyllium husk can help contribute to weight loss. Read on to find out how.
Psyllium husk has been gaining attention as a natural alternative to GLP-1 medications (GLP-1s) like Wegovy and Mounjaro, [1, 2] which are FDA-approved for weight loss. While some claim that psyllium husk can replicate the appetite-suppressing effects of GLP-1s, this isn’t entirely accurate. [3]
GLP-1 medications work by targeting hunger receptors in the brain and slowing digestion, which directly reduces appetite. [4] Psyllium husk, on the other hand, curbs hunger by forming a gel-like substance in your stomach, which physically takes up space and makes you feel less hungry. [5]
Both GLP-1 medications and psyllium husk contribute to feelings of fullness, but they work in different ways.
GLP-1s mimic a gut hormone that slows digestion and signals your brain to feel less hungry. Psyllium husk, as a soluble fiber, enhances satiety by absorbing water and expanding in your digestive system, helping you feel fuller for longer. While this natural process doesn't replicate the hormonal effects of GLP-1s, it can still be a useful tool in managing portion sizes and reducing snacking.
Unlike GLP-1s, which directly regulate blood sugar levels, psyllium husk supports healthy glucose levels in a different way. It traps sugars and carbohydrates in your digestive tract, slowing their absorption into the bloodstream. [6]
Additionally, psyllium husk promotes overall gut health by aiding regular bowel movements and preventing constipation, a common side effect of GLP-1s. [7] While it’s not a substitute for prescription treatments, increasing your fiber intake with psyllium husk can complement your weight loss efforts.
Aside from aiding weight loss efforts, there are other science-backed health benefits of psyllium husk.
Research shows that psyllium husk can help lower cholesterol levels, particularly LDL cholesterol (the “bad” cholesterol) associated with a higher risk of heart disease. By binding to cholesterol in the digestive system, psyllium husk helps to remove it from the body before it can be absorbed. [8]
Psyllium husk can help keep blood sugar levels healthy. A recent study found that taking psyllium husk lowered fasting blood sugar levels (the amount of sugar in your blood after you haven’t eaten anything for at least 8 hours) and improved long-term blood sugar control. [9]
Psyllium husk helps improve gut health by supporting good bacteria in your stomach. A study found that taking psyllium husk made stools softer by adding more water, and increased the number of healthy gut bacteria. This can lead to a healthier digestive system overall. [10]
Like any supplement, psyllium husk can cause side effects, but many people either don’t experience any or only have mild symptoms that go away on their own. Common side effects include stomach pain, cramps, and bloating, which can be similar to GLP-1s. [11] If these symptoms become severe or don’t go away, reach out to your healthcare provider for advice.
In rare cases, psyllium can cause serious side effects. Seek medical attention immediately if you have trouble swallowing or notice symptoms of an allergic reaction.
The amount of psyllium husk you need depends on your current fiber intake and your health goals. To meet your daily fiber needs, you might require multiple doses per day, depending on the product you’re using.
The current psyllium husk recommendations for adults with constipation in the USA is 25g per day for women and 38g per day for men. [12]
It’s essential to drink at least one full glass of water with each dose of psyllium husk, and continue to stay hydrated throughout the day to avoid constipation. Psyllium husk shouldn’t be your only source of fiber; instead, aim for a balanced diet that includes a variety of fiber-rich foods like fruits, vegetables, and whole grains.
For added convenience, psyllium husk can be mixed into foods like yogurt, oatmeal, smoothies, or even baked goods to make it easier to incorporate into your daily routine.
GLP-1s, such as Wegovy and Mounjaro, are FDA-approved treatments for weight loss that mimic a natural hormone in the body called glucagon-like peptide-1 (and glucose-dependent insulinotropic peptide in the case of Mounjaro). [1, 2]
GLP-1s promote weight loss by targeting receptors in the brain involved in appetite regulation, slowing digestion, and improving blood sugar control. They are prescription-based and often recommended for people living with obesity, or those struggling with weight-related health conditions. Proven to be highly effective, GLP-1s typically require weekly injections and careful monitoring by a healthcare provider.
Psyllium husk and GLP-1s function in completely different ways. Evidence surrounding the role of psyllium husk in aiding weight loss is mixed, with some studies finding it effective, [13] and others not. [14] In contrast, GLP-1s are scientifically proven to aid weight loss, with results demonstrating up to 20.9% of your body weight in just over a year. [1]
Psyllium husk is a soluble fiber that works by expanding in the stomach, creating a sense of fullness that can help control appetite and reduce overeating. It may be a helpful addition to a weight management plan, especially for those looking to increase their fiber intake, but is not a substitute for the clinically-proven benefits of GLP-1s.
One of the most significant differences between psyllium husk and GLP-1s is the cost. Psyllium husk is widely available from health and wellness stores and is inexpensive, often costing less than $20 depending on the brand and dosage. In contrast, GLP-1s can be more expensive, with monthly costs reaching $1,000 or more. However, at Levity we offer Compounded Semaglutide*, which contains the same active ingredient as Wegovy but is the unbranded alternative, which is available at a much lower price.
Psyllium husk is available in several forms, including powder and capsules. The powdered form is popular and easy to mix into liquids or food. Capsules are a convenient option for those who prefer a no-fuss approach, though they may require multiple servings to achieve the desired fiber intake. It’s essential to choose the form that works best for your lifestyle while ensuring you meet your fiber goals.
Incorporating psyllium husk into your daily routine can be easy and tasty with a bit of creativity. Psyllium powder can be added to smoothies, yogurt, or oatmeal for a fiber boost without altering the flavor significantly. For savory dishes, psyllium husk can be sprinkled into soups or stews to thicken them while adding a fiber-rich element. If you prefer a drinkable option, you can mix psyllium husk with water or juice, though be sure to consume it quickly after mixing, as it thickens rapidly. Always ensure that you are drinking plenty of water when consuming psyllium to avoid digestive discomfort.
When adding psyllium husk into your routine, it’s important to consider both the timing and portion size. A common recommendation is to start with one teaspoon of psyllium husk powder per day and gradually increase the dosage as your body adjusts to the added fiber. Ideally, psyllium husk should be taken with a full glass of water to prevent it from becoming too thick and potentially causing discomfort.
It may be beneficial to take psyllium husk before meals to increase the feeling of fullness and reduce overall food intake. Be mindful of your body’s response and adjust accordingly, making sure to stay hydrated throughout the day to prevent constipation.
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